Download and read online Introducing Epigenetics in PDF and EPUB Epigenetics is the most exciting field in biology today, developing our understanding of how and why we inherit certain traits, develop diseases and age, and evolve as a species. This non-fiction comic book introduces us to genetics, cell biology and the fascinating science of epigenetics, which is rapidly filling in the gaps in our knowledge, allowing us to make huge advances in medicine. We’ll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.
Download and read online Introducing Game Theory in PDF and EPUB When should you adopt an aggressive business strategy? How do we make decisions when we don’t have all the information? What makes international environmental cooperation possible? Game theory is the study of how we make a decision when the outcome of our moves depends on the decisions of someone else. Economists Ivan and Tuvana Pastine explain why, in these situations, we sometimes cooperate, sometimes clash, and sometimes act in a way that seems completely random. Stylishly brought to life by award-winning cartoonist Tom Humberstone, Game Theory will help readers understand behaviour in everything from our social lives to business, global politics to evolutionary biology. It provides a thrilling new perspective on the world we live in.
Download and read online The Epigenetics Revolution in PDF and EPUB "Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being."--Jacket.
Download and read online The Developing Genome in PDF and EPUB Includes bibliographical references (pages 275-300) and index
Download and read online DNA in PDF and EPUB Traces the history of scientific studies into the nature of DNA and examines the impact of DNA research and genetic engineering on society.
Download and read online Epigenetics in PDF and EPUB Discusses epigenetics--the study of genetic changes through environmental factors--and explains some genetic questions left unanswered by current theories, including psychological differences in identical twins.
Download and read online Epigenetics in PDF and EPUB The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.
Download and read online Herding Hemingway s Cats in PDF and EPUB The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work? There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. Figuring out how it all works Â? how your genes build your body Â? is a major challenge for researchers around the world. And what they're discovering is that far from genes being a fixed, deterministic blueprint, things are much more random and wobbly than anyone expected. Drawing on stories ranging from six toed cats and stickleback hips to Mickey Mouse mice and zombie genes Â? told by researchers working at the cutting edge of genetics Â? Kat Arney explores the mysteries in our genomes with clarity, flair and wit, creating a companion reader to the book of life itself.
Download and read online Epigenetics in PDF and EPUB "The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does. Epigenetics brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It will therefore be an invaluable source of information about all aspects of this subject for undergraduate students, graduate students, and professionals alike. Topics included are the role of epigenetics in stem cells, the involvement of epigenetics with cancer, and the role of epigenetics in mental health. Key Features - Describes the two forms of epigenetic modification, DNA methylation and histone acetylation, and how they take place. - Section on how epigenetics controls cell function, including cellular differentiation and consequently the role of epigenetics in stem cells - Section on the role of epigenetics in disease only includes diseases where there is clear evidence of epigenetic involvement - Glossary explaining all the terms involved in epigenetics - Full-color figures"--Provided by publisher.
Download and read online Epigenetics in Human Disease in PDF and EPUB Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs
Download and read online Epigenetics in PDF and EPUB The book EPIGENETICS is a global update of Darwin's book The Origin of Species. There is no other book that embraces all of the events (political, socially, biologically, nutritionally, chemically and genetically) that have been spawned since the publication of The Origin of Species by Darwin more than 100 years ago. EPIGENETICS is required reading for the very survival of Americans and yes all of humanity - modern man has bet on the wrong horse to save them from disease and pestilence - the medical system has failed us fearfully. It is predictable that this book will impact the world of the everyday man, science, politics, social engineering and medicine to the same degree that Darwin's The Origin of Species did more than 100 years ago. This book will be welcomed and enjoyed by religious leaders, community leaders, educators, parents and students of biology, nutrients and genetics in all forms. The general public will obviously be the larger market. Dr. Wallach has been lecturing 300 times per year to national and international audiences for more than 20 years. Dr.s Wallach and Ma have 10 best- selling books that were self-published (the best known Dead Doctors Don't Lie -hundreds of thousands sold - a favorite with Amazon.com) and dozens of CD titles - the most listened to of which is Dead Doctors Don't Lie which has sold just short of 200 million copies - Dr. Wallach's audience is very large and very loyal. Historically, Wallach's audiences range from 100 to 500 people, however, in the last 10 years enlarged by simulcast technology his audiences can range into the tens of thousands. For 18 years, Dr. Wallach has been the host of two one hour interactive radio talk shows that air M-F from 12:00 - 2:00 PST. Since 2011 Wallach has also been allied with the GCN radio network that has 1,342 stations.
Download and read online Epigenetic Gene Expression and Regulation in PDF and EPUB Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science
Download and read online Introducing Chaos in PDF and EPUB "Introducing Chaos" explains how chaos makes its presence felt in many varieties of event, from the fluctuation of animal populations to the ups and downs of the stock market. It also examines the roots of chaos in modern mathematics and physics, and explores the relationship between chaos and complexity, the new unifying theory which suggests that all complex systems evolve from a few simple rules.This is an accessible introduction to an astonishing and controversial theory that could dramatically change our view of the natural world and our place in a turbulent universe.
Download and read online Junk DNA in PDF and EPUB From the author of the acclaimed The Epigenetics Revolution (‘A book that would have had Darwin swooning’ – Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions – 98% of the human genome – were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself – and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.
Download and read online How to Tame a Fox and Build a Dog in PDF and EPUB Tucked away in Siberia, there are furry, four-legged creatures with wagging tails and floppy ears that are as docile and friendly as any lapdog. But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking. Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all. In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today. To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.